作者
M V Skulachev, Y N Antonenko, V N Anisimov, B V Chernyak, D A Cherepanov, V A Chistyakov, M V Egorov, N G Kolosova, G A Korshunova, K G Lyamzaev, E Y Plotnikov, V A Roginsky, A Y Savchenko, I I Severina, F F Severin, T P Shkurat, V N Tashlitsky, K M Shidlovsky, M Y Vyssokikh, A A Zamyatnin, D B Zorov, V P Skulachev
发表日期
2011/6/1
来源
Current drug targets
卷号
12
期号
6
页码范围
800-826
出版商
Bentham Science Publishers
简介
Plastoquinone, a very effective electron carrier and antioxidant of chloroplasts, was conjugated with decyltriphenylphosphonium to obtain a cation easily penetrating through membranes. This cation, called SkQ1, is specifically targeted to mitochondria by electrophoresis in the electric field formed by the mitochondrial respiratory chain. The respiratory chain also regenerates reduced SkQ1H2 from its oxidized form that appears as a result of the antioxidant activity of SkQ1H2. SkQ1H2 prevents oxidation of cardiolipin, a mitochondrial phospholipid that is especially sensitive to attack by reactive oxygen species (ROS). In cell cultures, SkQ1 and its analog plastoquinonyl decylrhodamine 19 (SkQR1) arrest H2O2-induced apoptosis. When tested in vivo, SkQs (i) prolong the lifespan of fungi, crustaceans, insects, fish, and mice, (ii) suppress appearance of a large number of traits typical for age-related senescence (cataract …
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MV Skulachev, YN Antonenko, VN Anisimov… - Current drug targets, 2011