作者
Walter O Spitzer, Samy Suissa, Pierre Ernst, Ralph I Horwitz, Brian Habbick, Donald Cockcroft, Jean-François Boivin, Mary McNutt, A Sonia Buist, Anthony S Rebuck
发表日期
1992/2/20
期刊
New England Journal of Medicine
卷号
326
期号
8
页码范围
501-506
出版商
Massachusetts Medical Society
简介
Background.
Morbidity and mortality from asthma appear to be increasing, and it has been suggested that medications used to treat asthma are contributing to this trend. We investigated a possible association between death or near death from asthma and the regular use of β2-agonist bronchodilators.
Methods.
Using linked health insurance data bases from Saskatchewan, Canada, we conducted a matched case–control study of subjects drawn from a cohort of 12,301 patients for whom asthma medications had been prescribed between 1978 and 1987. We matched 129 case patients who had fatal or near-fatal asthma with 655 controls (who had received medications for asthma but had not had fatal or near-fatal events) with respect to region of residence, age, receipt of social assistance, and previous hospitalization for asthma.
Results.
The use of β-agonists administered by a metered-dose inhaler was …
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