作者
Minseong Kim, WonJin Kim, GeunHyung Kim
发表日期
2017/12/20
期刊
ACS applied materials & interfaces
卷号
9
期号
50
页码范围
43459-43469
出版商
American Chemical Society
简介
Optimally designed three-dimensional (3D) biomedical scaffolds for skeletal muscle tissue regeneration pose significant research challenges. Currently, most studies on scaffolds focus on the two-dimensional (2D) surface structures that are patterned in the micro-/nanoscales with various repeating sizes and shapes to induce the alignment of myoblasts and myotube formation. The 2D patterned surface clearly provides effective analytical results of pattern size and shape of the myoblast alignment and differentiation. However, it is inconvenient in terms of the direct application for clinical usage due to the limited thickness and 3D shapeability. Hence, the present study suggests an innovative hydrogel or synthetic structure that consists of uniaxially surface-patterned cylindrical struts for skeleton muscle regeneration. The alignment of the pattern on the hydrogel (collagen) and poly(ε-caprolactone) struts was attained …
学术搜索中的文章
M Kim, WJ Kim, GH Kim - ACS applied materials & interfaces, 2017