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Energy harvesting from piezoelectric materials is quite common and has been studied for the past few decades. But recently, there have been a lot of new advancements in harnessing energy via piezoelectric materials. In this regard, several studies were carried out in analytical chemistry. This paper provides a detailed review of different piezoelectric materials, their structures, their fabrication processes, and their applications in analytical chemistry. Detection of the various gases percentage in ambient air is a valuable analytical chemistry technique. Additionally, the benefits of using piezoelectric materials, i.e., crystal for gas and liquid chromatography, virus detection including COVID-19 virus detection, water determination, trace metal analysis and the ability to measure micro weights with quartz crystal with some other applications are also described in this review. Energy harvesting is incredibly important and must be implemented on a large scale. So, developing self-powering devices can resolve the problems, and piezoelectric materials are gaining interest day by day because these materials help in energy generation.