作者
Paul Lacaze, Andrew Bakshi, Moeen Riaz, Galina Polekhina, Alice Owen, Harpreet S Bhatia, Pradeep Natarajan, Rory Wolfe, Lawrence Beilin, Stephen J Nicholls, Gerald F Watts, John J McNeil, Andrew M Tonkin, Sotirios Tsimikas
发表日期
2022/10/4
期刊
Journal of the American College of Cardiology
卷号
80
期号
14
页码范围
1287-1298
出版商
American College of Cardiology Foundation
简介
Background
The role of aspirin in reducing lipoprotein(a)-mediated atherothrombotic events in primary prevention is not established.
Objectives
This study sought to assess whether low-dose aspirin benefits individuals with elevated plasma lipoprotein(a)-associated genotypes in the setting of primary prevention.
Methods
The study analyzed 12,815 genotyped individuals ≥70 years of age of European ancestry and without prior cardiovascular disease events enrolled in the ASPREE (ASPirin in Reducing Events in the Elderly) randomized controlled trial of 100 mg/d aspirin. We defined lipoprotein(a)-associated genotypes using rs3798220-C carrier status and quintiles of a lipoprotein(a) genomic risk score (LPA-GRS). We tested for interaction between genotypes and aspirin allocation in Cox proportional hazards models for incidence of major adverse cardiovascular events (MACE) and clinically significant …
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P Lacaze, A Bakshi, M Riaz, G Polekhina, A Owen… - Journal of the American College of Cardiology, 2022