作者
Meghan E Jones, Jacqueline E Paniccia, Christina L Lebonville, Kathryn J Reissner, Donald T Lysle
发表日期
2018/9/15
期刊
Neuroscience
卷号
388
页码范围
45-56
出版商
Pergamon
简介
Maladaptive behavioral outcomes following stress have been associated with immune dysregulation. For example, we have previously reported that stress-induced dorsal hippocampal interleukin-1β signaling is critical to the development of stress-enhanced fear learning (SEFL). In parallel, astroglial signaling has been linked to the development of post-traumatic stress disorder (PTSD)-like phenotypes and our most recent studies have revealed astrocytes as the predominant cellular source of stress-induced IL-1β. Here, we used chemogenetic technology and morphological analyses to further explore dorsal hippocampal astrocyte function in the context of SEFL. Using a glial-expressing DREADD construct (AAV8-GFAP-hM4Di(Gi)-mCherry), we show that dorsal hippocampal astroglial Gi activation is sufficient to attenuate SEFL. Furthermore, our data provide the first initial evidence to support the function of the glial …
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ME Jones, JE Paniccia, CL Lebonville, KJ Reissner… - Neuroscience, 2018