作者
Sudeep S Gill, Susan E Bronskill, Sharon-Lise T Normand, Geoffrey M Anderson, Kathy Sykora, Kelvin Lam, Chaim M Bell, Philip E Lee, Hadas D Fischer, Nathan Herrmann, Jerry H Gurwitz, Paula A Rochon
发表日期
2007/6/5
期刊
Annals of internal medicine
卷号
146
期号
11
页码范围
775-786
出版商
American College of Physicians
简介
Background
Antipsychotic drugs are widely used to manage behavioral and psychological symptoms in dementia despite concerns about their safety.
Objective
To examine the association between treatment with antipsychotics (both conventional and atypical) and all-cause mortality.
Design
Population-based, retrospective cohort study.
Setting
Ontario, Canada.
Patients
Older adults with dementia who were followed between 1 April 1997 and 31 March 2003.
Measurements
The risk for death was determined at 30, 60, 120, and 180 days after the initial dispensing of antipsychotic medication. Two pairwise comparisons were made: atypical versus no antipsychotic use and conventional versus atypical antipsychotic use. Groups were stratified by …
引用总数
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SS Gill, SE Bronskill, SLT Normand, GM Anderson… - Annals of internal medicine, 2007