作者
Sean P Murphy, Margaret F Prescott, Alexander Camacho, Seethalakshmi R Iyer, Alan S Maisel, G Michael Felker, Javed Butler, Ileana L Piña, Nasrien E Ibrahim, Cheryl Abbas, John C Burnett Jr, Scott D Solomon, James L Januzzi
发表日期
2021/2/1
期刊
Heart failure
卷号
9
期号
2
页码范围
127-136
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess associations between longitudinal change in atrial natriuretic peptide (ANP) and reverse cardiac remodeling following initiation of sacubitril/valsartan in patients with heart failure with reduced ejection fraction (HFrEF).
Background
Neprilysin inhibition results in an increase of several vasoactive peptides that may mediate the beneficial effects of sacubitril/valsartan, including ANP.
Methods
In a prospective study of initiation and titration of sacubitril/valsartan in patients with HFrEF, blood was collected at scheduled time points into tubes containing protease inhibitors. This pre-specified exploratory analysis included patients in whom ANP was measured at baseline and serially through 12 months of treatment.
Results
Among 144 participants (mean age: 64.5 years; left ventricular ejection fraction: 30.8%), following initiation of sacubitril/valsartan, there was an early and …
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SP Murphy, MF Prescott, A Camacho, SR Iyer… - Heart failure, 2021