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Anesthesia-induced loss of consciousness is paralleled by a disruption of frontoparietal functional correlation, as measured by functional magnetic resonance imaging and electroencephalography. However, it is still unclear how anesthesia induces such a corticocortical disconnection.

Dynamic-resting state is a recent analytical method to study large-scale brain networks, allowing the clustering of functional magnetic resonance images into functional brain states.

When moving from wakefulness to anesthesia, the anatomical structure of connections between brain areas becomes the main driver of the repertoire of functional states. Subjects given anesthesia lose the ability to generate …