作者
Laura K Fonken, Matthew G Frank, Meagan M Kitt, Ruth M Barrientos, Linda R Watkins, Steven F Maier
发表日期
2015/3/1
期刊
Brain, behavior, and immunity
卷号
45
页码范围
171-179
出版商
Academic Press
简介
The circadian system regulates many physiological functions including inflammatory responses. For example, mortality caused by lipopolysaccharide (LPS) injection varies depending on the time of immunostimulation in mammals. The effects of more subtle challenges on the immune system and cellular mechanisms underlying circadian differences in neuroinflammatory responses are not well understood. Here we show that adult male Sprague–Dawley rats injected with a sub-septic dose of LPS during the light phase displayed elevated sickness behaviors and hippocampal cytokine production compared to rats injected during the dark phase. Microglia are the primary central nervous system (CNS) immune cell type and may mediate diurnal differences in sickness response, thus we explored whether microglia demonstrate temporal variations in inflammatory factors. Hippocampal microglia isolated from adult rats …
学术搜索中的文章
LK Fonken, MG Frank, MM Kitt, RM Barrientos… - Brain, behavior, and immunity, 2015