作者
Teresa Auguet, Ximena Terra, Jose Antonio Porras, Josep Maria Orellana-Gavaldà, Salomé Martinez, Carmen Aguilar, Anna Lucas, Silvia Pellitero, Merce Hernandez, Daniel Del Castillo, Cristobal Richart
发表日期
2013/2/1
期刊
Clinical Biochemistry
卷号
46
期号
3
页码范围
202-208
出版商
Elsevier
简介
OBJECTIVES
The few studies on the physiopathological role of visfatin in morbid obesity and the related metabolic diseases have led us to examine visfatin levels and its liver gene expression in morbidly obese women with non-alcoholic fatty liver disease (NAFLD).
DESIGN AND METHODS
We examined the circulating levels of visfatin by ELISA in serum samples from 95 morbidly obese women (MO) (BMI>40kg/m2) who underwent bariatric surgery and 38 normal weight control women (BMI<25kg/m2). We analysed visfatin liver and adipose tissue mRNA expression by RT-PCR. We evaluated the circulating levels and gene expression of adiponectin, resistin, RBP4, TNFα, IL6 and CRP.
RESULTS
Serum visfatin was significantly higher in MO compared with controls, and also in MO with NAFLD was significantly higher than MO with normal liver. We found that NAFLD diabetic patients presented similar serum …
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T Auguet, X Terra, JA Porras, JM Orellana-Gavaldà… - Clinical Biochemistry, 2013