作者
Luis Jara-Palomares, Remedios Otero, David Jimenez, Marc Carrier, Inna Tzoran, Benjamin Brenner, Mireia Margeli, Juan Manuel Praena-Fernandez, Elvira Grandone, Manuel Monreal, Hervè Decousus, Paolo Prandoni, Raquel Barba, Pierpaolo Di Micco, Laurent Bertoletti, Abilio Reis, Marijan Bosevski, Henri Bounameaux, Radovan Malý, Philip Wells, Manolis Papadakis, MA Aibar, M Alfonso, MI Asensio-Cruz, T Auguet, JI Arcelus, R Barba, M Barrón, B Barrón-Andrés, J Bascuñana, A Blanco-Molina, T Bueso, I Cañas, A Ceausu, N Chic, A Culla, R del Pozo, J del Toro, MC Díaz-Pedroche, JA Díaz-Peromingo, M Duffort, T Elias-Hernández, C Falgá, C Fernández-Aracil, C Fernández-Capitán, MA Fidalgo, C Font, L Font, P Gallego, MA García, F García-Bragado, M García-Rodenas, V Gómez, J González, E Grau, A Grimón, R Guijarro, L Guirado, J Gutiérrez, G Hernández-Comes, L Hernández-Blasco, E Hernando-López, L Jara-Palomares, MJ Jaras, D Jiménez, MD Joya, P Llamas, R Lecumberri, JL Lobo, L López-Jiménez, R López-Reyes, JB López-Sáez, MA Lorente, A Lorenzo, A Maestre, PJ Marchena, M Martín, F Martín-Martos, M Monreal, JA Nieto, S Nieto, A Núñez, MJ Núñez, M Odriozola, S Otalora, R Otero, A Ovejero, JM Pedrajas, G Pérez, C Pérez-Ductor, ML Peris, JA Porras, O Reig, A Riera-Mestre, D Riesco, A Rivas, MA Rodríguez-Dávila, V Rosa, P Ruiz-Artacho, N Ruiz-Giménez, JC Sahuquillo, MC Sala-Sainz, A Sampériz, R Sánchez, O Sanz, S Soler, B Sopeña, JM Suriñach, C Tolosa, J Trujillo-Santos, F Uresandi, B Valero, R Valle, J Vela, P Vicente, G Vidal, A Villalobos, J Villalta, T Vanassche, P Verhamme, P Wells, J Hirmerova, R Malý, E Salgado, L Bertoletti, A Bura-Riviere, D Farge-Bancel, A Hij, I Mahé, A Merah, F Moustafa, M Papadakis, A Braester, B Brenner, I Tzoran, G Antonucci, G Barillari, A Bertone, F Bilora, C Bortoluzzi, M Ciammaichella, C Di Girolamo, P Di Micco, R Duce, P Ferrazzi, M Giorgi-Pierfranceschi, E Grandone, C Lodigiani, R Maida, D Mastroiacovo
发表日期
2017/3/1
期刊
Chest
卷号
151
期号
3
页码范围
564-571
出版商
Elsevier
简介
Background
The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE.
Methods
We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period.
Results
Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap …
引用总数
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