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Study Design:

Randomized, double blind, placebo-controlled trial with a crossover design.

Objective:

To evaluate cranberry tablets for the prevention of urinary tract infection (UTI) in spinal cord injured (SCI) patients.

Setting:

Spinal Cord Injury Unit of a Veterans Administration Hospital, MA, USA.

Methods:

Subjects with spinal cord injury and documentation of neurogenic bladder were randomized to receive 6 months of cranberry extract tablet or placebo, followed by the alternate preparation for an additional 6 months. The primary outcome was the incidence of UTI.

Results:

Forty-seven subjects completed the trial. We found a reduction in the likelihood of UTI and symptoms for any month while receiving the cranberry tablet (P< 0.05 for all). During the cranberry period, 6 subjects had 7 UTI, compared with 16 subjects and 21 UTI in the placebo period (P< 0.05 for both number of subjects and incidence). The frequency of …