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Epidermal pH is an indication of the skin's physiological condition. For example, pH of wound can be correlated to angiogenesis, protease activity, bacterial infection, etc. Chronic nonhealing wounds are known to have an elevated alkaline environment, while healing process occurs more readily in an acidic environment. Thus, dermal patches capable of continuous pH measurement can be used as point‐of‐care systems for monitoring skin disorder and the wound healing process. Here, pH‐responsive hydrogel fibers are presented that can be used for long‐term monitoring of epidermal wound condition. pH‐responsive dyes are loaded into mesoporous microparticles and incorporated into hydrogel fibers using a microfluidic spinning system. The fabricated pH‐responsive microfibers are flexible and can create conformal contact with skin. The response of pH‐sensitive fibers with different compositions and …