作者
Eric Konofal, Michel Lecendreux, Juliette Deron, Martine Marchand, Samuele Cortese, Mohammed Zaïm, Marie Christine Mouren, Isabelle Arnulf
发表日期
2008/1/1
期刊
Pediatric neurology
卷号
38
期号
1
页码范围
20-26
出版商
Elsevier
简介
Iron deficiency has been suggested as a possible contributing cause of attention deficit hyperactivity disorder (ADHD) in children. This present study examined the effects of iron supplementation on ADHD in children. Twenty-three nonanemic children (aged 5-8 years) with serum ferritin levels <30 ng/mL who met DSM-IV criteria for ADHD were randomized (3:1 ratio) to either oral iron (ferrous sulfate, 80 mg/day, n = 18) or placebo (n = 5) for 12 weeks. There was a progressive significant decrease in the ADHD Rating Scale after 12 weeks on iron (−11.0 ± 13.9; P < 0.008), but not on placebo (3.0 ± 5.7; P = 0.308). Improvement on Conners’ Parent Rating Scale (P = 0.055) and Conners’ Teacher Rating Scale (P = 0.076) with iron supplementation therapy failed to reach significance. The mean Clinical Global Impression-Severity significantly decreased at 12 weeks (P < 0.01) with iron, without change in the placebo …
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E Konofal, M Lecendreux, J Deron, M Marchand… - Pediatric neurology, 2008