作者
Michael Marks, Oriol Mitjà, Christian Bottomley, Cynthia Kwakye, Wendy Houinei, Mathias Bauri, Paul Adwere, Abdul A Abdulai, Fredrick Dua, Laud Boateng, James Wangi, Sally-Ann Ohene, Regina Wangnapi, Shirley V Simpson, Helen Miag, Kennedy K Addo, Laud A Basing, Damien Danavall, Kai H Chi, Allan Pillay, Ronald Ballard, Anthony W Solomon, Cheng Y Chen, Sibauk V Bieb, Yaw Adu-Sarkodie, David CW Mabey, Kingsley Asiedu, Wendy Hounei, Sayy-Ann Ohene, Sivuak V Bieb, Nsire Agana, Edwin Ampadu, Kwame Amponsah-Achiano, Asare Bediako, Michael Biredu, Kyei Faried, Ahmed Iddrisu, Nana K Kotey, George NY Yeboah, Philip El-Duah, Richard Phillips, Fred Binka, Frank Nyonator, Anthony Zunuo, Mercy A Ackumey, Ivy Amanor, Christian Bnosu, Sieghard Frischmann, Patrick Lammie, Diana Martin, Tun Ye, Eva Christophel, Alexandre Tiendrebeogo, Lasse Vestergard, Quique Bassat, Yazid Abdad, Henson Dima, Bethuel Kotty, Kaiok Mamore, Walerius Manup, Benson Olowau, Enoch O Agyei, David Agyemang, Ebenezer P Ako, Prince Antwi, Jane Darko, Ophelia O Darko, Phylis Darko, Bertha Duodu, Daniel Jabasi, Fuseini L Karim, Obed K Koomson, Bernard A Labri, John Nartey, Randsford Tamatey, Benjamin Yirenkyi, Mercy Arhin, Frank Biney, Juliana O Danso, Martin A Dei, Moses Djan, Samuel Sasu, Brefo A Solomon, Victor Torvinya, Hagar Amankwaah, James Baffoe, Lydia Keteku, Kofi Kondobala, Rita D Lomotey, Augustina A Nartey, Paul Oppong, Millicent A Quainoo, Theophilus Abotsi, Dzighordi Agebshie, Amos Ameamu, Paul Angwaawie, Rose Ayibor, Margaret Mwingmendeli, John Nakodia, Amatus Nambagyira, Dominic Nanga, Nichola Tetteh, Augustine Wanaom
发表日期
2018/4/1
期刊
The Lancet Global Health
卷号
6
期号
4
页码范围
e401-e410
出版商
Elsevier
简介
Background
A dose of 30 mg/kg of azithromycin is recommended for treatment of yaws, a disease targeted for global eradication. Treatment with 20 mg/kg of azithromycin is recommended for the elimination of trachoma as a public health problem. In some settings, these diseases are co-endemic. We aimed to determine the efficacy of 20 mg/kg of azithromycin compared with 30 mg/kg azithromycin for the treatment of active and latent yaws.
Methods
We did a non-inferiority, open-label, randomised controlled trial in children aged 6–15 years who were recruited from schools in Ghana and schools and the community in Papua New Guinea. Participants were enrolled based on the presence of a clinical lesion that was consistent with infectious primary or secondary yaws and a positive rapid diagnostic test for treponemal and non-treponemal antibodies. Participants were randomly assigned (1:1) to receive either standard …
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M Marks, O Mitjà, C Bottomley, C Kwakye, W Houinei… - The Lancet Global Health, 2018