作者
Jeremy Davis-Turak, Tracy L Johnson, Alexander Hoffmann
发表日期
2018/11/16
期刊
Nucleic acids research
卷号
46
期号
20
页码范围
10598-10607
出版商
Oxford University Press
简介
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairing of exons with remarkable fidelity. Some exons are known to be skipped or included in the mature mRNA in a cell type- or context-dependent manner (cassette exons), thereby contributing to the diversification of the human proteome. Interestingly, splicing is initiated (and sometimes completed) co-transcriptionally. Here, we develop a kinetic mathematical modeling framework to investigate alternative co-transcriptional splicing (CTS) and, specifically, the control of cassette exons’ inclusion. We show that when splicing is co-transcriptional, default splice patterns of exon inclusion are more likely than when splicing is post-transcriptional, and that certain exons are more likely to be regulatable (i.e. cassette exons) than others, based on the exon–intron structure context. For such regulatable exons …
学术搜索中的文章
J Davis-Turak, TL Johnson, A Hoffmann - Nucleic acids research, 2018