作者
Genevieve Konopka, Tara Friedrich, Jeremy Davis-Turak, Kellen Winden, Michael C Oldham, Fuying Gao, Leslie Chen, Guang-Zhong Wang, Rui Luo, Todd M Preuss, Daniel H Geschwind
发表日期
2012/8/23
期刊
Neuron
卷号
75
期号
4
页码范围
601-617
出版商
Elsevier
简介
Understanding human-specific patterns of brain gene expression and regulation can provide key insights into human brain evolution and speciation. Here, we use next-generation sequencing, and Illumina and Affymetrix microarray platforms, to compare the transcriptome of human, chimpanzee, and macaque telencephalon. Our analysis reveals a predominance of genes differentially expressed within human frontal lobe and a striking increase in transcriptional complexity specific to the human lineage in the frontal lobe. In contrast, caudate nucleus gene expression is highly conserved. We also identify gene coexpression signatures related to either neuronal processes or neuropsychiatric diseases, including a human-specific module with CLOCK as its hub gene and another module enriched for neuronal morphological processes and genes coexpressed with FOXP2, a gene important for language evolution …
学术搜索中的文章
G Konopka, T Friedrich, J Davis-Turak, K Winden… - Neuron, 2012