作者
Christopher M Davenport, Rajit Rajappa, Ljudmila Katchan, Charlotte R Taylor, Ming-Chi Tsai, Caleb M Smith, Johannes W de Jong, Don B Arnold, Stephan Lammel, Richard H Kramer
发表日期
2021/1/6
期刊
Neuron
卷号
109
期号
1
页码范围
123-134. e4
出版商
Elsevier
简介
The excitatory synapse between hippocampal CA3 and CA1 pyramidal neurons exhibits long-term potentiation (LTP), a positive feedback process implicated in learning and memory in which postsynaptic depolarization strengthens synapses, promoting further depolarization. Without mechanisms for interrupting positive feedback, excitatory synapses could strengthen inexorably, corrupting memory storage. Here, we reveal a hidden form of inhibitory synaptic plasticity that prevents accumulation of excitatory LTP. We developed a knockin mouse that allows optical control of endogenous α5-subunit-containing γ-aminobutyric acid (GABA)A receptors (α5-GABARs). Induction of excitatory LTP relocates α5-GABARs, which are ordinarily extrasynaptic, to inhibitory synapses, quashing further NMDA receptor activation necessary for inducing more excitatory LTP. Blockade of α5-GABARs accelerates reversal learning, a …
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CM Davenport, R Rajappa, L Katchan, CR Taylor… - Neuron, 2021