作者
Carolina Bigatti, Paolo Cravedi, Gian Marco Ghiggeri, Andrea Angeletti
发表日期
2024/5
期刊
Nephrology Dialysis Transplantation
卷号
39
期号
Supplement_1
页码范围
gfae069-0425-2748
出版商
Oxford University Press
简介
Background and Aims
Common treatments for multidrug-resistant and multidrug-dependent nephrotic syndrome (NS) are inconsistently effective and burdened by long-term toxicities. Moreover, affected patients are at high risk of progression to end-stage kidney failure.
Objective
To test the safety/efficacy profile of combined single infusion of rituximab and daratumumab in inducing proteinuria remission in multidrug resistant nephrotic syndrome and maintaining drug free disease remission in patients with multidrug-dependent nephrotic syndrome after removal of oral immunosuppression.
Method
We here present a Phase 2 Proof-of-Concept single-arm clinical trial, that enrolled consecutive participants at the Nephrology Unit of the IRCCS Giannina Gaslini Children's Hospital in Genoa, Italy, between September 2021 and March 2023. Enrolled patients, aged …
学术搜索中的文章
C Bigatti, P Cravedi, GM Ghiggeri, A Angeletti - Nephrology Dialysis Transplantation, 2024