作者
Asghar Aghamohammadi, Nima Rezaei, Reza Yazdani, Samaneh Delavari, Necil Kutukculer, Ezgi Topyildiz, Ahmet Ozen, Safa Baris, Elif Karakoc-Aydiner, Sara Sebnem Kilic, Hulya Kose, Nesrin Gulez, Ferah Genel, Ismail Reisli, Kamel Djenouhat, Azzeddine Tahiat, Rachida Boukari, Samir Ladj, Reda Belbouab, Yacine Ferhani, Brahim Belaid, Reda Djidjik, Nadia Kechout, Nabila Attal, Khalissa Saidani, Ridha Barbouche, Aziz Bousfiha, Ali Sobh, Ragheed Rizk, Marwa H Elnagdy, Mona Al-Ahmed, Salem Al-Tamemi, Gulnara Nasrullayeva, Mehdi Adeli, Maryam Al-Nesf, Amel Hassen, Cybel Mehawej, Carla Irani, Andre Megarbane, Jessica Quinn, László Maródi, Vicki Modell, Fred Modell, Waleed Al-Herz, Raif S Geha, Hassan Abolhassani
发表日期
2021/8
期刊
Journal of clinical immunology
卷号
41
期号
6
页码范围
1339-1351
出版商
Springer US
简介
Background
Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis.
Methods
We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers.
Results
We identified 17,120 patients …
学术搜索中的文章
A Aghamohammadi, N Rezaei, R Yazdani, S Delavari… - Journal of clinical immunology, 2021