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Background:

The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disease.

Methods:

The serum level of IL-33 and total IgE in 89 asthmatic patients and 57 controls were analyzed. The association of levels of IL-33 with the severity of disease, levels of total IgE, measures of spirometry (forced expiratory volume in 1 s [FEV1]), age, sex, presence or absence of other allergic diseases, and the disease duration was evaluated.

Results:

Higher levels of IL-33 and total IgE were detected in asthmatic patients compared with controls (P= 0.0001 and P= 0.008, respectively). In the asthmatic group, a significant direct association of IL-33 with age (P= 0.02, R= 0.23) and with total IgE level (P= 0.003, R= 0.31) were observed, but there was no relationship between …