作者
Eric Hesse, Gerald Kluge, Azeddine Atfi, Diego Correa, Carl Haasper, Georg Berding, Hoen-oh Shin, Jörg Viering, Florian Länger, Peter M Vogt, Christian Krettek, Michael Jagodzinski
发表日期
2010/5/1
期刊
Bone
卷号
46
期号
5
页码范围
1457-1463
出版商
Elsevier
简介
Large segmental defects of the weight bearing long bones are very difficult to reconstruct. Current treatment options are afflicted with several limitations and disadvantages. We describe a novel approach to regenerate a segmental long bone defect in a patient using a multiple disc graft. Decellularized bovine trabecular bone discs were seeded with autologous bone marrow cells and cultured in a perfusion chamber for three weeks. Multiple cell-seeded discs were implanted to close a 72mm defect of the distal tibia in a 58-year-old woman, and fixed by an intramedullary nail. Bone formation was assessed non-invasively by plain radiographs and 18F-labeled sodium fluoride-based co-registration of positron emission- and computed tomography (PET/CT). Bone was actively formed around the grafted defect as early as six weeks after surgery. Because the tibia was sufficiently stabilized, the patient was able to freely …
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E Hesse, G Kluge, A Atfi, D Correa, C Haasper… - Bone, 2010