作者
Xiaoyu Du, Hongzhao You, Yulin Li, Yuan Wang, Peng Hui, Bokang Qiao, Jie Lu, Weihua Zhang, Shanshan Zhou, Yang Zheng, Jie Du
发表日期
2018/10/25
期刊
Scientific reports
卷号
8
期号
1
页码范围
15809
出版商
Nature Publishing Group UK
简介
The incidence of in-hospital cardiovascular adverse events (AEs) in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI) is relatively high. Identification of metabolic markers could improve our understanding of the underlying pathological changes in these patients. We aimed to identify associations between concentrations of plasma metabolites on admission and development of in-hospital AEs in post-PCI patients with STEMI. We used targeted mass spectrometry to measure plasma concentrations of 26 amino acid metabolites on admission in 96 patients with STEMI who subsequently developed post-PCI AEs and in 96 age- and sex-matched patients without post-PCI cardiovascular AEs. Principal component analysis (PCA) revealed that PCA-derived factors, including branched chain amino acids (BCAAs), were associated with increased …
学术搜索中的文章
X Du, H You, Y Li, Y Wang, P Hui, B Qiao, J Lu… - Scientific reports, 2018