作者
Shuai Zhang, Xiaoyu Kan, Yulin Li, Ping Li, Congcong Zhang, Guang Li, Jie Du, Bin You
发表日期
2018/3/1
期刊
Journal of Vascular Surgery
卷号
67
期号
3
页码范围
899-908. e1
出版商
Mosby
简介
Objective
It is known that T lymphocytes are activated in human abdominal aortic aneurysms (AAAs). γδT cells, as a subset of T cells, play a role in many inflammation-related diseases. However, whether γδT cells participate in the formation of AAA remains unknown. In this study, we explored the role of γδT cells in AAA lesions.
Methods and Results
Using the porcine pancreatic elastase-induced AAA model, we found that knock out of γδT cells significantly attenuated AAA formation. To elucidate how γδT cells contribute to AAA, microarray analysis was performed, which found that the phosphoinositide 3-kinase/AKT signaling pathway was activated in elastase-perfused γδT knockout (γδT KO) mice. By studying differentially expressed genes involved in phosphoinositide 3-kinase signaling, we found that proliferation-related genes (Sos1, Mtor, Myc) were upregulated whereas apoptosis-related genes (Pten, Bcl1, Bad …
学术搜索中的文章
S Zhang, X Kan, Y Li, P Li, C Zhang, G Li, J Du, B You - Journal of Vascular Surgery, 2018