作者
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Günther, Gloria Faerber, Christoph Sponholz, Marcus Franz, André Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W Pletz, Jan F Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A Borger, Michael Bauer, Frank M Brunkhorst, Torsten Doenst
发表日期
2022/3/29
期刊
Circulation
卷号
145
期号
13
页码范围
959-968
出版商
Lippincott Williams & Wilkins
简介
Background
Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE surgery may lead to a sudden release of inflammatory mediators, which is associated with postoperative organ dysfunction. We investigated the effect of hemoadsorption during IE surgery on postoperative organ dysfunction.
Methods
This multicenter, randomized, nonblinded, controlled trial assigned patients undergoing cardiac surgery for IE to hemoadsorption (integration of CytoSorb to cardiopulmonary bypass) or control. The primary outcome (change in sequential organ failure assessment score [ΔSOFA]) was defined as the difference between the mean total postoperative SOFA score, calculated maximally to the 9th postoperative day, and the basal SOFA score. The analysis was by modified intention to treat. A predefined intergroup comparison was performed using a linear mixed …
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M Diab, T Lehmann, W Bothe, P Akhyari, S Platzer… - Circulation, 2022