作者
Chi-Shin Wu, Sheng-Chang Wang, I-Shou Chang, Keh-Ming Lin
发表日期
2009/7/1
期刊
The American journal of geriatric psychiatry
卷号
17
期号
7
页码范围
614-620
出版商
Elsevier
简介
Objectives
The aim of this study was to examine the association between long-term benzodiazepines (BZDs) use and the risk of dementia.
Design
Population-based nested case–control study of dementia.
Setting
All subjects were aged 45 and older and enrolled in the National Health Insurance Research Database in Taiwan, 1997–2004.
Participants
Cases (N = 779) were patients who were identified with dementia at least two times in their outpatient claims. They were individually matched to six comparison subjects (N = 4,626) based on age and gender.
Measurements
BZD usage (average dosage per year, average days per year, and cumulative dose and periods) and potential confounding comobidities, including cardiovascular and psychiatric diseases.
Results
Subjects with dementia had higher cumulative dose, longer duration of BZDs exposure, and more likelihood to be long-term BZDs users.
Conclusion
Our …
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CS Wu, SC Wang, IS Chang, KM Lin - The American journal of geriatric psychiatry, 2009
