作者
Anil K D’Cruz, Richa Vaish, Neeti Kapre, Mitali Dandekar, Sudeep Gupta, Rohini Hawaldar, Jai Prakash Agarwal, Gouri Pantvaidya, Devendra Chaukar, Anuja Deshmukh, Shubhada Kane, Supreeta Arya, Sarbani Ghosh-Laskar, Pankaj Chaturvedi, Prathamesh Pai, Sudhir Nair, Deepa Nair, Rajendra Badwe
发表日期
2015/8/6
期刊
New England Journal of Medicine
卷号
373
期号
6
页码范围
521-529
出版商
Massachusetts Medical Society
简介
Background
Whether patients with early-stage oral cancers should be treated with elective neck dissection at the time of the primary surgery or with therapeutic neck dissection after nodal relapse has been a matter of debate.
Methods
In this prospective, randomized, controlled trial, we evaluated the effect on survival of elective node dissection (ipsilateral neck dissection at the time of the primary surgery) versus therapeutic node dissection (watchful waiting followed by neck dissection for nodal relapse) in patients with lateralized stage T1 or T2 oral squamous-cell carcinomas. Primary and secondary end points were overall survival and disease-free survival, respectively.
Results
Between 2004 and 2014, a total of 596 patients were enrolled. As prespecified by the data and safety monitoring committee, this report summarizes results for the first 500 patients (245 in the elective-surgery group and 255 in the …
学术搜索中的文章
AK D'Cruz, R Vaish, N Kapre, M Dandekar, S Gupta… - New England Journal of Medicine, 2015