作者
Feng Wang, XiuZhi Tian, Lu Zhang, ChangJiu He, PengYun Ji, Yu Li, DunXian Tan, GuoShi Liu
发表日期
2014/2/1
期刊
Fertility and Sterility
卷号
101
期号
2
页码范围
577-586. e1
出版商
Elsevier
简介
Objective
To analyze the potential beneficial effects and mechanisms of action of resveratrol on the maturation of bovine oocytes that were incubated in different concentrations of resveratrol (0.1, 1.0, or 10.0 μM) as germinal vesicle–stage oocytes.
Design
In vitro prospective study.
Setting
University research laboratory.
Animal(s)
Animal models for human studies.
Intervention(s)
In vitro culture in the presence of various concentrations of the antioxidant resveratrol.
Main Outcome Measure(s)
Parameters of hormone levels, oocyte nuclear maturation, cumulus expansion, levels of intracellular glutathione and reactive oxygen species, embryonic cleavage, blastocyst formation, gene expression associated with mature bovine oocytes and cumulus cells, and level of sirtuin 1 gene expression.
Result(s)
Resveratrol statistically significantly increased progesterone secretion and decreased estradiol-17β secretion by cumulus cells …
学术搜索中的文章
F Wang, XZ Tian, L Zhang, CJ He, PY Ji, Y Li, DX Tan… - Fertility and Sterility, 2014