作者
Lorena Pinheiro Figueiredo, Paulo Victor dos Santos Lima Paim, Thiago Cerqueira-Silva, Carolina Cincurá Barreto, Marcus Miranda Lessa
发表日期
2024/2/23
期刊
Brazilian Journal of Otorhinolaryngology
卷号
90
期号
01
页码范围
101356
出版商
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
简介
Objectives
Olfactory loss is a recognized long-term dysfunction after Coronavirus Disease 2019 (COVID-19) infection. This investigation aimed to assess the effect of alpha-lipoic acid as an adjuvant treatment of olfactory training on the improvement of smell loss in post-COVID-19 patients.
Methods
This randomized controlled trial included 128 adult outpatients who had persistent smell loss for more than 3-months after COVID-19 infection. The participants were randomly allocated into two groups: the intervention treatment group, which received alpha-lipoic acid associated to olfactory training, and comparison treatment group, which received placebo pills associated to olfactory training. The participants were followed-up for 12-weeks. Olfactory dysfunction was assessed in terms of Visual Analog Scale (VAS), and the Connecticut Chemosensory Clinical Research Center (CCCRC) test for the Brazilian population.
Results
A total of 100 participants completed the follow-up period and were analyzed in this study. Both groups have improved CCCRC score (p= 0.000), olfactory threshold (p= 0.000), identification score (p= 0.000) and VAS score (p= 0.000) after 12-weeks follow-up. No significant differences were determined between the intervention and comparison treatment groups in CCCRC score (p= 0.63), olfactory threshold (p= 0.50), identification score (p= 0.96) and VAS score (p= 0.97). In all these criteria, comparison treatment group went slightly worse. At the endpoint of the study, the frequency of anosmia reduced to 2% in the intervention treatment group and to 7.8% in the …
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LP Figueiredo, PVSL Paim, T Cerqueira-Silva… - Brazilian Journal of Otorhinolaryngology, 2024