作者
Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Thelma Beatriz González-Castro, Candelario Rodríguez-Pérez, María Lilia López-Narváez, José Manuel Rodríguez-Pérez, José Francisco Cámara-Álvarez
发表日期
2016/11/1
来源
Medicine
卷号
95
期号
44
页码范围
e5298
出版商
LWW
简介
Background:
Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk.
Methods:
Relevant studies were enrolled by searching databases systematically. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Subgroup analyses were conducted for diagnostic and ethnicity. The heterogeneity among each of the studies was calculated by using Cochran Qtest and the inconsistency index (I 2), and Begg's funnel plot and Egger's tests were performed to evaluate publication bias.
Result:
Sixty four studies involving a total of 19,715 cases and 33,397 controls were included in this meta-analysis. We found that the L55M polymorphism …
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