作者
Carlos Tovilla-Zárate, Isela Juárez-Rojop, Teresa Ramón-Frias, Mario Villar-Soto, Sherezada Pool-García, Beatriz Camarena Medellín, Alma D Genis Mendoza, Lilia López Narvaez, Nicolini Humberto
发表日期
2011/12
期刊
BMC psychiatry
卷号
11
页码范围
1-8
出版商
BioMed Central
简介
Background
The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.
Methods
We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.
Results
No significant differences were found in the distribution of alleles (χ2 = 0.33, 1 df, p = 0.56) or …
学术搜索中的文章
No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data
C Tovilla-Zárate, I Juárez-Rojop, T Ramón-Frias… - BMC psychiatry, 2011