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The structural features of Iran’s health system obligate the development of information technology in medical field and design of an effective e-health system. Due to the importance of this issue, the current study was performed to identify the effective elements on e-health deployment in order to codify a comprehensive plan for Iran. The practical, descriptive-comparative study was conducted using semiqualitative methods with mathematical analysis. The study populations included the following countries: Australia, Germany, Japan, Sweden, Britain, Turkey and Iran. Due to the comparative nature of the study, there were no samples and the selected countries were chosen as the sources of information. This study was performed in four stages including studying the current situation and the history of issue in Iran through documents and evidences, comprehensive study of e-health in selected countries by searching through books, materials and also the web, suggesting the primary proposal and eventually determining the proposal’s credibility and presenting the final plan using the semi-Delphi technique. The findings of the study indicated that e-health deployment priorities included individual health care identifier (IHI), patient ID, e-health card, increasing investment in information technology, electronic appointment registration, electronic prescribing and finally, telemedicine service. Strategies commonly aimed to use the information technology to provide health care services based on patients centrality. E-health infrastructures included physical networks, legal infrastructures, education, preparation and performance of e-health operation. The …