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It has been estimated that 2–4 million people in developing countries possess HCV infection driven by unsafe injection drug use each year that is extending to other population. High-risk injection behaviors are the leading cause of HCV infections among PWIDs. The purpose of this study was to survey prevalence of HCV and risk factors associated with HCV among injecting drug users. This cross-sectional study was carried out on 410 injection drug users in Kermanshah that were recruited through peer-referral and convenience sampling from two Drop-In Centers (DICs). Data were collected using structured information form, and data analysis was done with descriptive and logistic regression. A total of 410 men who injected drugs participated in this study. The mean age ± standard deviation (SD) was 33.2 ± 7.3 (range 19–58) years, Overall, the prevalence of HCV infections was 42 …