作者
Fabio Guolo, Luana Fianchi, Paola Minetto, Marino Clavio, Michele Gottardi, Sara Galimberti, Giuliana Rizzuto, Michela Rondoni, Giambattista Bertani, Michela Dargenio, Atto Bilio, Barbara Scappini, Patrizia Zappasodi, Anna Maria Scattolin, Francesco Grimaldi, Giuseppe Pietrantuono, Pellegrino Musto, Marco Cerrano, Stefano D’Ardia, Ernesta Audisio, Alessandro Cignetti, Crescenza Pasciolla, Francesca Pavesi, Anna Candoni, Carmela Gurreri, Monica Morselli, Caterina Alati, Nicola Fracchiolla, Giovanni Rossi, Manuela Caizzi, Fabrizio Carnevale-Schianca, Agostino Tafuri, Giuseppe Rossi, Felicetto Ferrara, Livio Pagano, Roberto Massimo Lemoli
发表日期
2020/10/6
期刊
Blood Cancer Journal
卷号
10
期号
10
页码范围
96
出版商
Nature Publishing Group UK
简介
Secondary acute myeloid leukemia (sAML) poorly responds to conventional treatments and allogeneic stem cell transplantation (HSCT). We evaluated toxicity and efficacy of CPX-351 in 71 elderly patients (median age 66 years) with sAML enrolled in the Italian Named (Compassionate) Use Program. Sixty days treatment-related mortality was 7% (5/71). The response rate at the end of treatment was: CR/CRi in 50/71 patients (70.4%), PR in 6/71 (8.5%), and NR in 10/71 (19.7%). After a median follow-up of 11 months relapse was observed in 10/50 patients (20%) and 12 months cumulative incidence of relapse (CIR) was 23.6%. Median duration of response was not reached. In competing risk analysis, CIR was reduced when HSCT was performed in first CR (12 months CIR of 5% and 37.4%, respectively, for patients receiving (=20) or not (=30) HSCT, p = 0.012). Twelve-months OS was 68.6% (median not …
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F Guolo, L Fianchi, P Minetto, M Clavio, M Gottardi… - Blood Cancer Journal, 2020
