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The timing and circumstances where tracheostomies are performed varies in clinical practice with conflicting guidelines. Data on tracheostomized patients with Coronavirus Disease 2019 (COVID-19) is more limited. Our study aimed to compare characteristics of tracheostomized patients with and without COVID-19. We hypothesized that demographics and treatment characteristics at the time of tracheostomy may vary between the two groups that may result in different clinical outcomes. We performed a retrospective observational case-control study of 604 consecutive tracheostomized patients hospitalized in an intensive care unit (ICU) of one of Mount Sinai Health System hospitals between March 2020 to September 2021. We analyzed clinical and treatment characteristics at the time of tracheostomy of patients with and without COVID-19. 398 COVID-19 negative (COVID-) and …