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There is currently limited data on tracheostomized patients with Coronavirus Disease 2019 (COVID-19) with conflicting guidelines. Our study aimed to compare outcomes of tracheostomized patients with and without COVID-19 in hope to provide optimal management strategies for critically ill patients. We performed a retrospective observational case-control study of 604 consecutive tracheostomized patients hospitalized in an intensive care unit (ICU) of one of Mount Sinai Health System hospitals between March 2020 to September 2021. We evaluated and compared clinical outcomes of length of stay (LOS), time to ventilator liberation, speech valve placement, decannulation, and mortality between patients with and without COVID-19. 398 COVID-19 negative (COVID-) and 206 COVID-19 positive (COVID+) patients were tracheostomized. Both groups had a similar mean age (62 …