作者
Janvi Paralkar, Jennifer Fung
发表日期
2020/10/1
期刊
Chest
卷号
158
期号
4
页码范围
A1424
出版商
Elsevier
简介
DISCUSSION: Due to the low prevalence of sarcomatoid carcinoma, there is a limited data regarding clinical manifestations of disease. According to the 2015 World Health Organization Classification of Lung Tumors, sarcomatoid carcinoma includes 5 subtypes (including spindle cell carcinoma) and suggests molecular testing to assess for genetic abnormalities, which can help direct treatment options. Typically, immunohistory chemistry for spindle cell carcinoma is positive for cytokeritin and vimentin, but negative for desmin, CD34, and S100 protein. Most are also positive for PDL-1 which opens the possibility for immunotherapy. Our patient was positive for AE1/AE3, which is of epithelial origin and negative for PDL-1. While surgical resection is the mainstay of treatment for local disease, there is minimal data on the treatment of metastatic disease and are usually treated similarly to non-small cell lung cancer …
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