作者
Anudishi Tyagi, Bin Yuan, Stanley Ly, Fouad El-Dana, Vinitha Kuruvilla, Qi Zhang, Xin Zhou, Benoit deCrombrugghe, Marina Konopleva, Michael Andreeff, Venkata Lokesh Battula
发表日期
2020/9/1
期刊
Clinical Lymphoma Myeloma and Leukemia
卷号
20
页码范围
S195
出版商
Elsevier
简介
Context
We have reported that AML cells induce osteogenic differentiation in MSCs to facilitate AML growth in the bone marrow (BM) (Battula et al. JCI Insight, 2017). However, the effect of AML cells on various osteo-lineage cells in the BM microenvironment is not known.
Objective
i) To assess the stage-specific subsets of osteoblast lineage induced by AML cells in BME. ii) To investigate the effect of new bone formation using AML patient-derived-xenograft (PDX) mouse model.
Design
In this study, we used inducible triple transgenic mice with osterix (Osx) or osteocalcin (Ocn) reporter genes with genotype Osx-CreERt2; Ocn-GFP; ROSA-tdTomato to determine the effect of AML cells on various osteo-lineage cells. In addition, we used AML-PDX mouse models to investigate the impact of AML cell growth on new bone formation.
Results
In transgenic mice implanted with syngenic AML cells, we found a 3-4 fold increase …
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A Tyagi, B Yuan, S Ly, F El-Dana, V Kuruvilla, Q Zhang… - Clinical Lymphoma Myeloma and Leukemia, 2020