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Background:

Vancomycin pharmacokinetics are best described using a 2-compartment model. However, 1-compartment population models are commonly used as the basis for dose prediction software. Therefore, the validity of using a 1-compartment model to guide vancomycin drug dosing was examined.

Methods:

Published plasma concentration–time data from adult subjects (n= 30) with stable renal function administered a single intravenous infusion of vancomycin were extracted from previous studies. The vancomycin area under the curve (AUC 0–∞) was calculated for each subject using noncompartmental methods (AUC NCA) and by fitting 1-(AUC 1CMT), 2-(AUC 2CMT), and 3-(AUC 3CMT) compartment infusion models. The optimal model fit was determined using the Akaike information criterion and visual inspection of the residual plots. The individual compartmental AUC 0–∞ values from the 1-and 2 …