作者
Nuno J Machado, Ana Patrícia Simões, Henrique B Silva, Ana Paula Ardais, Manuella P Kaster, Pedro Garção, Diana I Rodrigues, Daniela Pochmann, Ana Isabel Santos, Inês M Araújo, Lisiane O Porciúncula, Ângelo R Tomé, Attila Köfalvi, Jean-Marie Vaugeois, Paula Agostinho, Malika El Yacoubi, Rodrigo A Cunha, Catarina A Gomes
发表日期
2017/3
期刊
Molecular neurobiology
卷号
54
页码范围
1552-1563
出版商
Springer US
简介
Caffeine prophylactically prevents mood and memory impairments through adenosine A2A receptor (A2AR) antagonism. A2AR antagonists also therapeutically revert mood and memory impairments, but it is not known if caffeine is also therapeutically or only prophylactically effective. Since depression is accompanied by mood and memory alterations, we now explored if chronic (4 weeks) caffeine consumption (0.3 g/L) reverts mood and memory impairment in helpless mice (HM, 12 weeks old), a bred-based model of depression. HM displayed higher immobility in the tail suspension and forced swimming tests, greater anxiety in the elevated plus maze, and poorer memory performance (modified Y-maze and object recognition). HM also had reduced density of synaptic (synaptophysin, SNAP-25), namely, glutamatergic (vGluT1; −22 ± 7 %) and GABAergic (vGAT; −23 ± 8 %) markers in the hippocampus …
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NJ Machado, AP Simões, HB Silva, AP Ardais… - Molecular neurobiology, 2017