作者
Maria D Salazar Garcia, Nayoung Sung, Thomas M Mullenix, Svetlana Dambaeva, Kenneth Beaman, Alice Gilman‐Sachs, Joanne Kwak‐Kim
发表日期
2016/7
期刊
American Journal of Reproductive Immunology
卷号
76
期号
1
页码范围
70-81
简介
Problem
Association between PAI‐1 4G/5G polymorphism and reproductive failures has been postulated. We aimed to investigate its impact on metabolic, hormonal, and immune profiles of women with reproductive failures.
Method of study
A retrospective study was carried out in 208 women with a history of reproductive failure. Study patients were divided into three groups: women with repeated implantation failure (RIF, n = 40), recurrent pregnancy loss (RPL, n = 113), and both RIF and RPL (n = 55). Fertile controls were 92.
Results
PAI‐1 4G/4G was prevalent in RPL, RIF, and RIF/RPL groups when compared with controls (P = 0.003) and associated with increased risks of RIF, RPL, and RIF with RPL (OR = 4.5, 2.2 and 2.7). Women with PAI‐1 4G/4G have significantly higher BMI, glucose, and PAI‐1 levels and lower NK cytotoxicity when compared with women without PAI‐1 4G/4G.
Conclusion
PAI‐1 4G/5G …
学术搜索中的文章
MD Salazar Garcia, N Sung, TM Mullenix, S Dambaeva… - American Journal of Reproductive Immunology, 2016