作者
Youssef Derbala, Haidy Elazzamy, Mahmood Bilal, Rachel Reed, Maria Dinorah Salazar Garcia, Annie Skariah, Svetlana Dambaeva, Emilio Fernandez, Alfredo Germain, Alice Gilman‐Sachs, Kenneth Beaman, Joanne Kwak‐Kim
发表日期
2019/7
期刊
American Journal of Reproductive Immunology
卷号
82
期号
1
页码范围
e13128
简介
Problem
Mast cells (MC) have been known to play an important role in inflammation and angiogenesis by secreting numerous mediators, such as proteases, gelatinases, and proteoglycans. Three different MC subtypes were found in the endometrial layers of the uterus. In this study, we aim to investigate the role of endometrial MCs in recurrent pregnancy losses (RPL).
Method of study
Endometrial biopsy was performed 5‐7 days post‐ovulation (implantation window) in women with a history of two or more RPL (n = 46) and normal fertile women (n = 10). Quantitative RT‐PCR was performed to detect the expression of various mast cell mediators. Endometrial samples were evaluated using immunohistochemistry for c‐kit receptor (CD117) and tryptase (MC activation marker).
Results
Mast cells were present throughout the entire layers of the endometrium; their count was elevated in RPL patients as compared to …
学术搜索中的文章
Y Derbala, H Elazzamy, M Bilal, R Reed… - American Journal of Reproductive Immunology, 2019