作者
Maryam Khatoon, Muhammad Farhan Sohail, Gul Shahnaz, Fiza ur Rehman, Asim ur Rehman, Naseem Ullah, Umair Amin, Gul Majid Khan, Kifayat Ullah Shah
发表日期
2019/10
期刊
AAPS PharmSciTech
卷号
20
页码范围
1-12
出版商
Springer International Publishing
简介
Proniosomes offer excellent potential for improved drug delivery, through versatile routes, by overcoming the permeation barriers faced by several drugs. The study was aimed to develop a thiomer gel containing duloxetine proniosomes for the intranasal delivery, improving its bioavailability and brain delivery through olfactory system. Duloxetine-loaded proniosomes were optimized through Design-Expert Software, prepared by coacervation phase separation method and then characterized in vitro for different vesicle features, and permeation enhancement potential using various techniques. The formulation F2, out of all the trials, fulfilled the maximum requisite of highest entrapment efficiency (76.21 ± 1.24%) and minimum vesicle size (223.91 ± 11.07 nm). The F2 was embedded in thiolated chitosan gel rendering it mucoadhesive and further characterized. The in vitro release showed a sustained drug …
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M Khatoon, MF Sohail, G Shahnaz, F ur Rehman… - AAPS PharmSciTech, 2019