作者
Ming-Hui Chen, Joseph G Ibrahim, Debajyoti Sinha
发表日期
1999/9/1
期刊
Journal of the American Statistical Association
卷号
94
期号
447
页码范围
909-919
出版商
Taylor & Francis Group
简介
We consider Bayesian methods for right-censored survival data for populations with a surviving (cure) fraction. We propose a model that is quite different from the standard mixture model for cure rates. We provide a natural motivation and interpretation of the model and derive several novel properties of it. First, we show that the model has a proportional hazards structure, with the covariates depending naturally on the cure rate. Second, we derive several properties of the hazard function for the proposed model and establish mathematical relationships with the mixture model for cure rates. Prior elicitation is discussed in detail, and classes of noninformative and informative prior distributions are proposed. Several theoretical properties of the proposed priors and resulting posteriors are derived, and comparisons are made to the standard mixture model. A real dataset from a melanoma clinical trial is discussed in detail.
引用总数
20002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242101176810112124211933333432424241383556313412
学术搜索中的文章
MH Chen, JG Ibrahim, D Sinha - Journal of the American Statistical Association, 1999