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The CLSA is a formal collaboration among three clinical data collection sites and two laboratories, funded through the NIMH (USA) to carry out a genetic linkage study of autism. The goal is to genotype 150 families in two replicate samples. We are currently completing our first genome screen of 76 families, including 72 sibling pairs and 4 sibling trios and 148 of 153 possible parents. There are several instances of non-Mendelian transmission of markers on chromosome 15q. At the time of the conference, we will present the statistical analysis of the entire genome screen, as well as results from our follow-up of chromosomal regions (eg, 7, 15, 16) previously reported as providing suggestive evidence of linkage to autism.