作者
Humaid O Al-Shamsi, Jeremy Jones, Yazan Fahmawi, Ibrahim Dahbour, Aziz Tabash, Reham Abdel-Wahab, Ahmed OS Abousamra, Kenna R Shaw, Lianchun Xiao, Manal M Hassan, Benjamin R Kipp, Scott Kopetz, Amr S Soliman, Robert R McWilliams, Robert A Wolff
发表日期
2016/12
期刊
Journal of gastrointestinal oncology
卷号
7
期号
6
页码范围
882
出版商
AME Publications
简介
Background
The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in colorectal cancer (CRC) differ among populations. The aim of this study was to assess mutation frequencies in the Arab population and determine their correlations with certain clinicopathological features.
Methods
Arab patients from the Arab Gulf region and a population of age-and sex-matched Western patients with CRC whose tumors were evaluated with next-generation sequencing (NGS) were identified and retrospectively reviewed. The mutation rates of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC were recorded, along with clinicopathological features. Other somatic mutation and their rates were also identified. Fisher’s exact test was used to determine the association between mutation status and clinical features.
Results
A total of 198 cases were identified; 99 Arab patients and 99 Western patients. Fifty-two point …
学术搜索中的文章
HO Al-Shamsi, J Jones, Y Fahmawi, I Dahbour… - Journal of gastrointestinal oncology, 2016