作者
Peter Borchmann, Helen Goergen, Carsten Kobe, Andreas Lohri, Richard Greil, Dennis A Eichenauer, Josée M Zijlstra, Jana Markova, Julia Meissner, Michaela Feuring-Buske, Andreas Hüttmann, Judith Dierlamm, Martin Soekler, Hans-Joachim Beck, Wolfgang Willenbacher, Wolf-Dieter Ludwig, Thomas Pabst, Max S Topp, Felicitas Hitz, Martin Bentz, Ulrich Bernd Keller, Dagmar Kühnhardt, Helmut Ostermann, Norbert Schmitz, Bernd Hertenstein, Walter Aulitzky, Georg Maschmeyer, Tom Vieler, Hans Eich, Christian Baues, Harald Stein, Michael Fuchs, Georg Kuhnert, Volker Diehl, Markus Dietlein, Andreas Engert
发表日期
2017/12/23
期刊
The Lancet
卷号
390
期号
10114
页码范围
2790-2802
出版商
Elsevier
简介
Background
The intensive polychemotherapy regimen eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses) is very active in patients with advanced-stage Hodgkin's lymphoma, albeit at the expense of severe toxicities. Individual patients might be cured with less burdensome therapy. We investigated whether metabolic response determined by PET after two cycles of standard regimen eBEACOPP (PET-2) would allow adaption of treatment intensity, increasing it for PET-2-positive patients and reducing it for PET-2-negative patients.
Methods
In this open-label, randomised, parallel-group phase 3 trial, we recruited patients aged 18–60 years with newly diagnosed, advanced-stage Hodgkin's lymphoma in 301 hospitals and private practices in Germany, Switzerland, Austria, the Netherlands, and the Czech Republic. After central review of PET …
学术搜索中的文章
P Borchmann, H Goergen, C Kobe, A Lohri, R Greil… - The Lancet, 2017