作者
Zheng-Pin Wang, Xin-Yi Mu, Meng Guo, Yi-Jing Wang, Zhen Teng, Guan-Ping Mao, Wan-Bao Niu, Li-Zhao Feng, Li-Hua Zhao, Guo-Liang Xia
发表日期
2014/3/14
期刊
Journal of Biological Chemistry
卷号
289
期号
12
页码范围
8299-8311
出版商
Elsevier
简介
Physiologically, only a few primordial follicles are activated to enter the growing follicle pool each wave. Recent studies in knock-out mice show that early follicular activation depends on signaling from the tuberous sclerosis complex, the mammalian target of rapamycin complex 1 (mTORC1), phosphatase and tensin homolog deleted on chromosome 10, and phosphatidylinositol 3-kinase (PI3K) pathways. However, the manner in which these pathways are normally regulated, and whether or not TGF-β acts on them are poorly understood. So, this study aims to identify whether or not TGF-β acts on the process. Ovary organ culture experiments showed that the culture of 18.5 days post-coitus (dpc) ovaries with TGF-β1 reduced the total population of oocytes and activated follicles, accelerated oocyte growth was observed in ovaries treated with TGF-βR1 inhibitor 2-(5-chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl …
学术搜索中的文章
ZP Wang, XY Mu, M Guo, YJ Wang, Z Teng, GP Mao… - Journal of Biological Chemistry, 2014