作者
Lili Zhang, Magid Awadalla, Syed S Mahmood, Anju Nohria, Malek ZO Hassan, Franck Thuny, Daniel A Zlotoff, Sean P Murphy, James R Stone, Doll Lauren Alexandra Golden, Raza M Alvi, Adam Rokicki, Maeve Jones-O’Connor, Justine V Cohen, Lucie M Heinzerling, Connor Mulligan, Merna Armanious, Ana Barac, Brian J Forrestal, Ryan J Sullivan, Raymond Y Kwong, Eric H Yang, Rongras Damrongwatanasuk, Carol L Chen, Dipti Gupta, Michael C Kirchberger, Javid J Moslehi, Otavio R Coelho-Filho, Sarju Ganatra, Muhammad A Rizvi, Gagan Sahni, Carlo G Tocchetti, Valentina Mercurio, Michael Mahmoudi, Donald P Lawrence, Kerry L Reynolds, Jonathan W Weinsaft, A John Baksi, Stephane Ederhy, John D Groarke, Alexander R Lyon, Michael G Fradley, Paaladinesh Thavendiranathan, Tomas G Neilan
发表日期
2020/5/7
期刊
European heart journal
卷号
41
期号
18
页码范围
1733-1743
出版商
Oxford University Press
简介
Aims
Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with ICI-associated myocarditis are presented.
Methods and results
From an international registry of patients with ICI-associated myocarditis, clinical, CMR, and histopathological findings were collected. Major adverse cardiovascular events (MACE) were a composite of cardiovascular death, cardiogenic shock, cardiac arrest, and complete heart block. In 103 patients diagnosed with ICI-associated myocarditis who had a CMR, the mean left ventricular ejection fraction (LVEF) was 50%, and 61% of patients had an LVEF ≥50%. Late gadolinium enhancement (LGE …
学术搜索中的文章
L Zhang, M Awadalla, SS Mahmood, A Nohria… - European heart journal, 2020